Samus vs. Iron Man would be interesting, if not for the fact that Samus never talks. - - Auto Merge - - Apparently I posted while you were still creating the poll.
Andre the Giant versus, maybe the giant from Jack and the Beanstalk or the Cyclops from the Odyssey? Honestly, there really is no real life person who compares to Andre. Oh, I know! Andre the Giant vs Rubeus Hagrid!